Thermo Fisher Scientific Steroidogenic Factor 1 (SF-1) (Transcription Factor) Monoclonal Antibody (NR5A1/3420)
Steroidogenic Factor 1 (SF-1) 단일클론 항체로 인간 시료 반응성이 우수하며, 핵 내 위치 특이성을 가집니다. 성 결정 및 스테로이드 생성 관련 연구에 적합합니다. Protein A/G 정제 및 PBS 버퍼로 안정화된 액상 형태로 제공됩니다.
- 카탈로그번호
- 2516-MSM6-P1
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | NR5A1/3420 |
| Immunogen | Recombinant fragment (around aa220–461) of human SF-1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is stable for 24 months.
- Positive Control: Human testis or adrenal cortical carcinoma
- Cellular Localization: Nucleus
Specificity Comments:
The protein encoded by this gene is a transcriptional activator involved in sex determination. It binds DNA as a monomer. Defects in this gene are associated with XY sex reversal and adrenal failure. SF-1 is an orphan nuclear receptor regulating steroidogenic enzyme gene expression. It is expressed in steroidogenic tissues such as adrenal cortex, testicular Sertoli and Leydig cells, ovarian theca, hypothalamus, and anterior pituitary. SF-1 is a key marker for determining adrenocortical origin of adrenal masses.
Target Information
Steroidogenic factor-1 (SF-1) is an orphan nuclear receptor essential for development and differentiation of endocrine organs including the hypothalamus, pituitary, gonads, and adrenal glands. It promotes transcriptional activity of steroidogenic enzymes from the cytochrome P450 family. SF-1 contains two activation domains (AF1 and AF2), which interact with nuclear receptors and coactivators such as SRC-1, GRIP1, CREB binding protein (CBP), and SMRT.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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