Thermo Fisher Scientific IRAK4 Polyclonal Antibody
Rabbit polyclonal antibody targeting human IRAK4 for use in WB and ICC/IF. Affinity purified, unconjugated, liquid form with 0.5 mg/mL concentration. Suitable for research use only; predicted reactivity with Monkey, Horse, and Bat.
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- 720328
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1–2 µg/mL
Immunocytochemistry (ICC/IF)
- Tested Dilution: 2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptides corresponding to Human IRAK4 (aa 40–56, 404–422) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 30% glycerol, 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2633260 |
Product Specific Information
These polyclonal antibodies are of rabbit origin, developed by immunizing animals with proteins or peptides. The antibody is affinity purified from rabbit sera and tested for functionality in relevant research applications.
Developed for Research Use Only and is non-hazardous or non-infectious in nature.
This antibody is predicted to react with Monkey, Horse, and Bat.
Target Information
IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. Overexpression of IRAK4 activates NF-kappa-B and MAPK pathways. IRAK4 interacts with and phosphorylates IRAK1.
IRAK4-deficient animals are completely resistant to LPS challenge. Animals and humans lacking IRAK4 show impaired responses to viral and bacterial challenges.
Members of the IRAK/Pelle family play a central role in IL-1R/TLR-mediated inflammatory responses and innate immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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