Thermo Fisher Scientific MAP2K3 Monoclonal Antibody (OTI1D3), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:200–1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step.
Recommended desalting product: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882)

Target Information

MAP2K3 (MEK3) is a dual-specificity protein kinase involved in cellular signal transduction pathways.
It phosphorylates and activates MAPK14/p38-MAPK and is required for glucose transporter expression.
Activation can occur via insulin, and RAS oncogene expression results in accumulation of active kinase, leading to constitutive MAPK14 activation and oncogenic transformation.
Inhibition of this kinase is implicated in the pathogenesis of Yersinia pseudotuberculosis.
Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported for MEK3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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