Thermo Fisher Scientific MAP2K3 Monoclonal Antibody (OTI1H6), TrueMAB
MAP2K3 단백질을 인식하는 Mouse IgG2a 단일클론 항체로, WB, IHC, ICC/IF에 사용 가능. 인간 단백질에 반응하며, 동결건조 형태로 제공. 연구용으로 신호전달 및 MAPK 경로 분석에 적합.
- 카탈로그번호
- CF505614
- 판매단위
- pk
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Thermo Fisher Scientific MAP2K3 Monoclonal Antibody (OTI1H6), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1H6 |
| Immunogen | Full length human recombinant protein of human MAP2K3 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
MAP2K3 (MEK3) is a dual-specificity protein kinase involved in cellular signal transduction pathways and necessary for glucose transporter expression. It phosphorylates and activates MAPK14/p38-MAPK and can be activated by insulin.
RAS oncogene expression induces accumulation of the active kinase form, leading to constitutive MAPK14 activation and oncogenic transformation. Inhibition of this kinase is linked to the pathogenesis of Yersinia pseudotuberculosis.
Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported for MEK3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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