Thermo Fisher Scientific MAP2K3 Monoclonal Antibody (OTI3C3), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:200–1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

MAP2K3 (MEK3) is a dual-specificity protein kinase involved in cellular signal transduction pathways and required for the expression of glucose transporter. It phosphorylates and activates MAPK14/p38-MAPK. Activation can occur via insulin signaling, and RAS oncogene expression leads to accumulation of the active kinase form, resulting in constitutive MAPK14 activation and oncogenic transformation of primary cells. Inhibition of this kinase is associated with the pathogenesis of Yersinia pseudotuberculosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported for MEK3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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