Thermo Fisher Scientific Phospho-YBX1 (Ser102) Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500 - 1:2,000

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic phosphorylated peptide around S102 of human YB-1/YBX1 (NP_004550.2). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:YBX1,uniProtId:P67809-1,ncbiNodeId:9606,antigenRange:102,antigenLength:324,antigenImageFileName:PA5-121354_YBX1_P67809-1_Rabbit.svg,antigenImageFileNamePDP:PA5-121354_YBX1_P67809-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.97 mg/mL

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2914926

Product Specific Information

Positive test controls include: HepG2. The target is usually found in the following locations: Cytoplasm, Cytoplasmic granule, Nucleus, Secreted.

Target Information

YBX1 binds to splice sites in pre-mRNA and regulates splice site selection. This protein binds and stabilizes cytoplasmic mRNA and contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors. It binds to promoters that contain a Y-box (5-CTGATTGGCCAA-3), such as HLA class II genes. It regulates the transcription of numerous genes and promotes separation of DNA strands that contain mismatches or are modified by cisplatin. It has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro), and it may play a role in DNA repair.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.