Thermo Fisher Scientific CD38 Monoclonal Antibody (90), FITC, eBioscience

Applications

Immunohistochemistry (IHC)

• Tested Dilution: Not specified
• Publications: View 1 publication

Flow Cytometry (Flow)

• Tested Dilution: 0.125 µg/test
• Publications: View 20 publications

Product Specifications

Available Formats

• Unconjugated
• Alexa Fluor 700
• APC
• APC-eFluor 780
• Biotin
• Brilliant UV 395
• Brilliant Violet 480
• Brilliant Violet 605
• eFluor 450
• Functional Grade
• PE
• PE-Cyanine5
• PE-Cyanine7
• PE-eFluor 610
• PerCP-eFluor 710
• Request custom conjugation

Product Specific Information

The 90 monoclonal antibody reacts with the mouse CD38 molecule, a ~42 kDa type II transmembrane protein. CD38 expression increases on B cells during differentiation, then decreases on germinal center B cells and mature plasma cells. It is also expressed on subsets of thymocytes, mature T cells, and NK cells.

Crosslinking of CD38 on mature resting B cells induces proliferation, enhanced by IL-4 and LPS co-stimulation. CD38 acts as a counter-receptor for CD31 and functions as an ectoenzyme with cyclase and hydrolase activity, involved in lymphocyte activation and differentiation.

Applications Reported: Flow cytometric analysis
Applications Tested: Tested on mouse splenocytes at ≤0.125 µg/test (100 µL final volume; 10⁵–10⁸ cells/test). Titrate for optimal performance.
Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser
Filtration: 0.2 µm post-manufacturing filtered

Target Information

CD38 (NAD⁺ glycohydrolase) is a type II transmembrane glycoprotein that induces activation, proliferation, and differentiation of mature lymphocytes, and mediates apoptosis in progenitor cells. It functions as a multi-catalytic ectoenzyme (ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, NAD⁺ glycohydrolase) and as a receptor.

Antibodies to CD38 are used for subtyping lymphomas and leukemias, detecting plasma cells (e.g., myelomas), and as markers for activated B and T cells. CD38 participates in cell adhesion, signal transduction, and calcium signaling, and is highly expressed in pancreas, liver, kidney, malignant lymphoma, and neuroblastoma.
Dysfunction of CD38 is associated with chronic lymphocytic leukemia and Richter’s Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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