Thermo Fisher Scientific CD38 Monoclonal Antibody (HIT2), FITC, eBioscience
사람 CD38 단백질을 인식하는 HIT2 클론 단일클론항체로, FITC 형광표지되어 유세포분석에 최적화됨. 5 µL/test 농도로 사용 가능하며, 488 nm 여기/520 nm 방출 특성. 인간 B세포, T세포, 단핵구 등 CD38 발현 세포 분석에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry (Flow) | 5 µL (1 µg)/test | View 17 publications |
| ELISA | – | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), FITC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HIT2 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1724062 |
Additional Available Formats
- Unconjugated
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Biotin
- Brilliant UV 805
- Brilliant Violet 421
- Brilliant Violet 480
- eFluor 450
- PE
- PE-Cyanine5
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 702
- Request custom conjugation
Product Specific Information
The HIT2 monoclonal antibody reacts with the human CD38 molecule, an approximately 45 kDa type II transmembrane protein. CD38 is expressed by thymocytes, peripheral B cells including plasma cells, activated T cells, and monocytes. CD38 is a counter-receptor for CD31 and has both cyclase and hydrolase enzymatic activity.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Pre-titrated and tested by flow cytometry using normal human peripheral blood cells
- Recommended Use: 5 µL (1 µg) per test in a final 100 µL staining volume
- Cell Range: 10⁵–10⁸ cells/test (empirically determined)
- Excitation: 488 nm
- Emission: 520 nm
- Laser: Blue Laser
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD38 (NAD⁺ glycohydrolase) is a type II transmembrane glycoprotein that induces activation, proliferation, and differentiation of mature lymphocytes and mediates apoptosis of myeloid and lymphoid progenitor cells. It functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, and possibly NAD⁺ glycohydrolase or as a cell surface receptor.
Antibodies to CD38 are useful for:
- Subtyping of lymphomas and leukemias
- Detection of plasma cells (e.g., myeloma identification)
- Marker for activated B and T cells
CD38 participates in cell adhesion, signal transduction, and calcium signaling. It is expressed at high levels in pancreas, liver, kidney, malignant lymphoma, and neuroblastoma. Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter’s Syndrome.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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