Thermo Fisher Scientific Phospho-ErbB3 (Tyr1289) Monoclonal Antibody (E.350.3)
Phospho-ErbB3 (Tyr1289) 단클론 항체로 인간 및 생쥐 시료에 반응하며, Western blot, IHC, IP에 적합합니다. HER3/ErbB3 인산화 부위를 인지하며, 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 |
| Immunoprecipitation (IP) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | E.350.3 |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pTyr1289 of human HER3/ErbB3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 113 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10982965 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
ErbB3 (c-erbB-3/HER-3) is a member of the type I family of growth factor receptors and binds to ligands in the heregulin family. ErbB3 is over-expressed in various tumors including prostate, bladder, breast, stomach, pancreas, and colon. Heregulin and EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents.
The ErbB3 gene is located on the long arm of human chromosome 12 (12q13) and transcribed into a 6.2 kb mRNA, translated into a 160/180 kDa glycoprotein. The gene encodes a transmembrane receptor tyrosine kinase that forms heterodimers with other EGF receptor family members possessing kinase activity. These heterodimers activate pathways leading to cell proliferation or differentiation.
Alternate transcriptional splice variants encoding different isoforms of ErbB3 have been characterized. One isoform lacks the intermembrane region, is secreted outside the cell, and modulates the activity of the membrane-bound form. Additional splice variants have been reported but not thoroughly characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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