Thermo Fisher Scientific LAMTOR1 Polyclonal Antibody
LAMTOR1 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 적합합니다. 인간, 마우스, 랫트 반응성을 가지며, 항원 친화 크로마토그래피로 정제된 액상형 제품입니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–2 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Rabbit polyclonal LAMTOR1 antibody raised against a 17 amino acid peptide near the amino terminus of human LAMTOR1 (within first 50 amino acids). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2890464 |
Product Specific Information
Positive controls that may be used include:
- A431 Cell Lysate
- Human Small Intestine Tissue Slide
Target Information
The Ragulator complex consists of three proteins—C11orf59, ROBLD3, and MAPKSP1—which target mTORC1 to lysosomal surfaces. This complex plays a role in endosomal trafficking and can be exploited by viruses such as coronavirus to enhance replication.
C11orf59 is regulated by cholesterol levels, participating in LDL uptake and cholesterol homeostasis. It interacts with PPAR-alpha to control lipid and carbohydrate metabolism in diabetes.
Most effects of C11orf59 are associated with mTORC1 kinase-mediated growth promotion, and dysregulation of the mTOR pathway may have metabolic implications.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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