Thermo Fisher Scientific TRPV4 Polyclonal Antibody
TRPV4 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼에 0.02% sodium azide가 포함되어 있습니다. 인간 시료 반응성이 있으며, 연구용으로 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | TRPV4 antibody was raised against an 18 amino acid peptide near the center of human TRPV4 (amino acids 380–430). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2890363 |
Product Specific Information
Positive controls that may be used include:
- SK-N-SH Cell Lysate
- Human Lung Tissue Slide
Target Information
TRPV4 (Transient Receptor Potential Cation Channel Subfamily V Member 4) is a cation-selective channel activated in response to systemic osmotic pressure. It is a non-selective calcium-permeant cation channel involved in osmotic sensitivity and mechanosensitivity.
TRPV4 belongs to the OSM9-like transient receptor potential channel (OTRPC) subfamily within the TRP superfamily of ion channels.
Mutations in the TRPV4 gene are associated with spondylometaphyseal and metatropic dysplasia, and hereditary motor and sensory neuropathy type IIC.
Diseases associated with TRPV4 include Metatropic Dysplasia and Spondylometaphyseal Dysplasia, Kozlowski Type.
Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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