Thermo Fisher Scientific VDAC Recombinant Rabbit Monoclonal Antibody (G8F6)
VDAC 단백질을 검출하기 위한 토끼 유래 재조합 단클론 항체. Western blot, IHC, ICC/IF에 적합. 미토콘드리아 외막 및 세포막 단백질 분석에 유용. 고특이성과 재현성 높은 결과 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | G8F6 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–283 of human VDAC1 / Porin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.21 mg/mL |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2802614 |
Product Specific Information
- Positive Samples: LO2, A-549, A-431, Raji, mouse heart, mouse kidney, mouse brain, rat heart, rat brain
- Cellular Location: Cell membrane, Membrane raft, Mitochondrion outer membrane, Multi-pass membrane protein
Target Information
Voltage-dependent anion channel (VDAC) proteins are abundant, pore-forming proteins belonging to the eukaryotic mitochondrial porins. They are located primarily in the mitochondrial outer membrane and also expressed in the plasma membrane.
At least three different VDAC genes have been identified in vertebrates. VDAC proteins play an essential role in cellular metabolism and the early stages of apoptosis.
VDAC constitutes a major pathway for metabolite exchange (e.g., ADP/ATP, succinate, citrate) between the cytosol and mitochondria. VDAC1 in the plasma membrane may also regulate apoptosis via its redox activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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