Thermo Fisher Scientific VDAC Recombinant Rabbit Monoclonal Antibody (G8F6)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

1:50-1:200

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Recombinant Monoclonal

Type

Antibody

Clone

G8F6

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-283 of human VDAC1 / Porin

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2802614

Product Specific Information

Positive Samples: LO2, A-549, A-431, Raji, mouse heart, mouse kidney, mouse brain, rat heart, rat brain; Cellular Location: Cell membrane, Membrane raft, Mitochondrion outer membrane, Multi-pass membrane protein

Target Information

Voltage-dependent anion channel (VDAC) proteins are abundant, pore-forming proteins belonging to the eukaryotic mitochondrial porins. It was discovered in the mitochondrial outer membrane. It also is expressed in the plasma membrane. At least three different VDAC genes have been identified in vertebrates. VDAC proteins are known to play an essential role in cellular metabolism and in the early stages of apoptosis. For example, VDAC constitutes a major pathway by which metabolites such as ADP/ATP, succinate and citrate are exchanged between the cytosol and mitochondria. And VDAC1 in the plasma membrane establishes a novel level of apoptosis regulation putatively via its redox activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.