Thermo Fisher Scientific THOC5 Polyclonal Antibody
THOC5 단백질을 표적하는 Rabbit Polyclonal 항체로, Human 및 Mouse 반응성이 있습니다. Western Blot, IHC, IP 등 다양한 응용에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 4°C에서 보관합니다.
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Thermo Fisher Scientific THOC5 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 25 and 75 of Human THO complex 5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
- Based on 100% sequence identity, this antibody is predicted to react with Rat and Bovine
Target Information
THOC5 is a component of the THO subcomplex within the TREX complex. The TREX complex associates specifically with spliced mRNA and is crucial for mRNA export. It binds upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to the 5′ end of mRNA. The TREX complex facilitates export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs via interactions between THOC4 and viral ORF57 protein. UAP56 bridges THOC4 and the THO complex. THOC5, together with THOC4, is involved in NXF1-NXT1 mediated nuclear export of HSP70 mRNA and may play roles in granulocyte and adipocyte differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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