Thermo Fisher Scientific Phospho-CD244 (Tyr271) Polyclonal Antibody
인간 CD244 (Tyr271) 인산화형을 인식하는 Goat Polyclonal 항체로, IP 및 ELISA에 적합합니다. 0.5 mg/mL 농도의 액상 형태이며, TBS(pH 7.3) + 0.5% BSA buffer에 보관됩니다. 연구용으로만 사용되며, NK 세포 관련 면역조절 연구에 활용됩니다.
- 카탈로그번호
- PA5141977
- 판매단위
- pk
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Thermo Fisher Scientific Phospho-CD244 (Tyr271) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunoprecipitation (IP) | 2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-EFLTIpYEDVKD |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2932641 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.
Target Information
CD244 (2B4, SLAMF4) is a cell surface receptor expressed on natural killer (NK) cells and some T cells that mediates non-major histocompatibility complex (MHC) restricted killing.
The interaction between NK cells and target cells via CD244 modulates NK-cell cytolytic activity.
CD244 interacts with SLAMF2, activating both SLAMF4- and SLAMF2-expressing cells.
Patients with systemic lupus erythematosus show reduced SLAMF4 expression on NK cells and monocytes, suggesting a role in autoimmune pathology.
Diseases associated with CD244 dysfunction include rheumatoid arthritis and lymphoproliferative syndrome.
Alternatively spliced transcript variants encoding different isoforms of CD244 have been identified.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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