Thermo Fisher Scientific MCK10 Polyclonal Antibody
Thermo Fisher Scientific의 MCK10 Polyclonal Antibody는 인간 DDR1 단백질을 표적으로 하는 토끼 다클론 항체로, Western blot, IHC, ICC/IF, Flow Cytometry에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 299–330 of human DDR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography, Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10981193 |
Target Information
DDR1 is a receptor tyrosine kinase activated by collagen and is reported to regulate adhesion, cell migration, and other cellular processes. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment, regulating cell growth, differentiation, and metabolism. The DDR1 protein is widely expressed in normal and transformed epithelial cells and activated by various types of collagen (types I–VI). Expression is prominent in epithelial tissues such as kidney, lung, gastrointestinal tract, and brain, and is overexpressed in several human tumors including breast, ovarian, esophageal, and pediatric brain cancers. The DDR1 gene is located on chromosome 6p21.3 near several HLA class I genes, and alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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