Thermo Fisher Scientific Phospho-RyR3 (Ser160) Polyclonal Antibody
RYR3 단백질의 Ser160 인산화 부위를 특이적으로 인식하는 폴리클로날 항체. Western blot에 적합하며, 인산화된 RYR3의 내인성 발현 검출 가능. Rabbit IgG 기반으로 PBS/glycerol 용액에 보관. 연구용으로만 사용 가능.
- 카탈로그번호
- PA5105062
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RYR3 (Accession Q15413), corresponding to amino acid residues around phosphorylated Ser160 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816535 |
Product Specific Information
This antibody detects endogenous levels of RYR3 only when phosphorylated at Ser160.
Target Information
RYR3 (Ryanodine Receptor 3) functions to release calcium from intracellular storage for use in many cellular processes. It plays a key role in skeletal muscle contraction by mediating calcium release from the sarcoplasmic reticulum following depolarization of T-tubules.
Two transcript variants encoding different isoforms of RYR3 have been identified. RYR3 contributes to calcium ion homeostasis and cellular signaling by regulating Ca²⁺ release from the sarcoplasmic and endoplasmic reticulum.
Diseases associated with RYR3 include Central Core Disease and Arrhythmogenic Right Ventricular Dysplasia 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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