Thermo Fisher Scientific ZBP1 Recombinant Rabbit Monoclonal Antibody (5H15L56)
ZBP1 단백질을 인식하는 재조합 토끼 단일클론 항체로, Western blot 및 Immunocytochemistry에 사용 가능. 인간에 반응하며, 마우스·랫·소에서도 반응 예측. Protein A로 정제된 액상형 항체로 안정적이며, 연구용으로 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 5H15L56 |
| Immunogen | Protein corresponding to human ZBP1 [aa6-aa166] |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2866458 |
Product Specific Information
This antibody is predicted to react with Mouse, Rat, and Bovine.
Target Information
Z-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Zalpha domain which binds specifically to left-handed Z-DNA and Z-RNA. ZBP1 was initially identified as a novel gene up-regulated in activated macrophages in mice bearing ascites tumors, suggesting a role in host response during neoplasia.
Recent studies indicate that cytosolic ZBP1 can act similarly to toll-like receptor TLR9 by detecting cytosolic double-stranded DNA and inducing type I interferon and other innate immune responses.
Binding of ZBP1 to dsDNA enhances its association with innate immune response proteins such as IRF3 and TBK1 (NAK). Multiple isoforms of ZBP1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: 703166_ZBP1_Q9H171-1_Rabbit.svg, 703166_ZBP1_Q9H171-1_Rabbit_PDP.jpeg)
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