Thermo Fisher Scientific SATB1 Recombinant Rabbit Monoclonal Antibody (5H18L16)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody is predicted to react with Mouse, Rat, and Bovine.

Target Information

SATB1 (DNA-binding protein SATB1) is a crucial silencing factor that contributes to the initiation of X inactivation mediated by Xist RNA during embryogenesis and in lymphoma. SATB1 binds to DNA at special AT-rich sequences (SATB1-binding sequences) and nuclear matrix- or scaffold-associated regions. It is thought to recognize the sugar-phosphate structure of double-stranded DNA. SATB1 acts as a transcriptional repressor controlling nuclear and viral gene expression in a phosphorylation- and acetylation-dependent manner by binding to matrix attachment regions and inducing local chromatin-loop remodeling. SATB1 modulates genes essential for the maturation of immune T-cell CD8SP from thymocytes. Alu-like motifs and SATB1-binding sites provide a unique chromatin context preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL1 and IL2RA in T-cells by binding to the same domain as HDAC1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.