Thermo Fisher Scientific HAS2 Monoclonal Antibody (4E7)
Human HAS2 단백질을 인식하는 Mouse IgG1 단일클론 항체로, WB, IHC, ICC/IF, ELISA 등 다양한 응용에 적합합니다. 고순도 Protein G 정제, 1 mg/mL 농도, PBS 및 sodium azide 포함. 연구용 전용 제품으로 안정적인 4°C 또는 -20°C 보관 가능.
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- MA517087
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Thermo Fisher Scientific HAS2 Monoclonal Antibody (4E7)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4E7 |
| Immunogen | Purified recombinant fragment of human HAS2 (amino acids: 67–170) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538558 |
Product Specific Information
MA5-17087 targets HAS2 in indirect ELISA, ICC, IHC, IF, and WB applications and shows reactivity with human samples.
The immunogen is a purified recombinant fragment of human HAS2 (amino acids 67–170) expressed in E. coli.
MA5-17087 detects HAS2, which has a predicted molecular weight of approximately 63.5 kDa.
Target Information
Hyaluronan (HA) is a high molecular weight unbranched polysaccharide synthesized by organisms ranging from bacteria to mammals and is a key component of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues linked by β-1,3 and β-1,4 glycosidic bonds.
HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane and extruded into the extracellular space. It functions in space filling, joint lubrication, and as a matrix for cell migration.
HA production increases during wound healing and tissue repair, supporting angiogenesis and fibroblast growth.
Alterations in HA levels are associated with inflammatory and degenerative diseases such as rheumatoid arthritis.
Interaction of HA with CD44 plays a role in leukocyte homing, and overexpression of HA receptors correlates with tumor metastasis.
HAS2 belongs to the vertebrate gene family encoding hyaluronan synthases and shares homology with glycosaminoglycan synthetase (DG42) from Xenopus laevis, as well as human and murine HAS1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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