Thermo Fisher Scientific GUCY1A3 Monoclonal Antibody (3G6B2)
GUCY1A3 단백질을 인식하는 Mouse monoclonal antibody (Clone 3G6B2). Western blot, IHC, ICC/IF, Flow cytometry, ELISA에 사용 가능. Human 및 비인간 영장류 반응성. Protein G 정제, 1 mg/mL 농도, PBS buffer에 0.05% sodium azide 포함.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 | - |
| Flow Cytometry (Flow) | 1:200–1:400 | - |
| ELISA | 1:10,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Non-human primate |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3G6B2 |
| Immunogen | Purified recombinant fragment of human GUCY1A3 (amino acids 22–214) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538557 |
Product Specific Information
MA5-17086 targets GUCY1A3 in indirect ELISA, FACS, ICC, IHC, IF, and WB applications, showing reactivity with human samples.
The immunogen is a purified recombinant fragment of human GUCY1A3 (amino acids 22–214) expressed in E. coli.
MA5-17086 detects GUCY1A3 with a predicted molecular weight of approximately 77.5 kDa.
Target Information
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family.
There are two forms of guanylate cyclase:
- Soluble form (GCS or sGC): Acts as a receptor for nitric oxide.
- Membrane-bound receptor form (GC): Functions as a peptide hormone receptor.
The GC-C protein consists of:
- Extracellular domain
- Single transmembrane domain
- Cytoplasmic region with kinase-like and catalytic domains
It exists as two differentially glycosylated forms:
- 130 kDa precursor (endoplasmic reticulum)
- 145 kDa mature form (plasma membrane)
Ligand binding to the extracellular domain of GC-C promotes accumulation of cGMP.
GC-C acts as the receptor for heat-stable enterotoxins from pathogenic E. coli, causing severe secretory diarrhea.
It also binds guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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