
Thermo Fisher Scientific Toralizumab Chimeric Recombinant Mouse Monoclonal Antibody (IDEC-131 (Toralizumab))
휴먼 CD40 리간드에 특이적인 비작용성 키메라 항체. HEK293 세포에서 발현된 리컴비넌트 마우스 IgG1 항체. 단백질 A 정제, 액상 형태로 1 mg/mL 농도. 염증 및 자가면역 연구용으로 적합.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: Assay-dependent
Inhibition Assays (IA)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | IDEC-131 (Toralizumab) |
| Immunogen | The original monoclonal antibody was generated by immunization with a soluble fusion protein of human gp39 (gp39-CD8). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074751 |
Product Specific Information
Specificity: This antibody is a non-agonistic antibody specific for human CD40 ligand.
Target Information
Toralizumab works by binding to interferon gamma, preventing it from interacting with its receptors on immune cells. This blocks downstream signaling pathways that lead to inflammation and tissue damage in autoimmune diseases. By blocking interferon gamma, toralizumab aims to reduce inflammation and prevent further tissue damage in affected individuals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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