Thermo Fisher Scientific CCR7 Chimeric Recombinant Rabbit Monoclonal Antibody (4B12)
Thermo Fisher Scientific의 CCR7 Chimeric Recombinant Rabbit Monoclonal Antibody (4B12)는 마우스 CCR7 단백질에 특이적인 항체로, ICC/IF, Flow Cytometry, IP 및 Functional Assay에 사용됩니다. HEK293 세포에서 발현되었으며 Protein A로 정제된 액상 형태로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
| Functional Assay | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 4B12 |
| Immunogen | This antibody was raised by immunizing rats with mouse CCR7 antigen. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074748 |
Product Specific Information
Specificity: This antibody is specific to the mouse CCR7 protein, which was confirmed by immunoprecipitation.
Target Information
CCR7 is a member of the G protein-coupled receptor family, a subfamily of chemokines. It was identified to be induced by Epstein Barr virus (EBV) and is thought to mediate EBV effects on B lymphocytes. CCR7 is expressed in blood, bone marrow, lymph node, and intestine, particularly in lymphoid tissues and activated B and T lymphocytes. It controls migration of memory T cells to inflamed tissues and stimulates dendritic cell maturation. The chemokine ligand CCL19/ECL is a specific ligand of this receptor. ESTs have been isolated from blood, embryo, lymph node, and thymus libraries. Receptors for the C-C chemokine family include CCR1, CCR2A, CCR3, CCR4, CCR5, and the Duffy blood group antigen. These receptors are important for T cell chemotaxis and migration of phagocytic cells to sites of inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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