Thermo Fisher Scientific CXCR5 Polyclonal Antibody, Biotin
CXCR5 단백질을 인식하는 Biotin 결합 폴리클로날 항체로, Western blot, IHC, ICC, ELISA 등 다양한 실험에 사용 가능. Human 시료 반응성, Rabbit IgG 호스트. 합성 펩타이드 면역원 기반으로 제작되어 높은 특이성과 안정성을 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
| Immunomicroscopy (IM) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to unique amino acid sequences on human CXCR5 protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CXCR5 (C-X-Chemokine Receptor Type 5, CD185), also known as Burkitt lymphoma receptor 1 (BLR1), belongs to the CXC chemokine receptor family. It is a G protein-coupled seven transmembrane receptor for chemokine BLC.
CXCR5 gene is specifically expressed in Burkitt’s lymphoma and lymphatic tissues such as follicles in lymph nodes and spleen. Studies indicate CXCR5 plays an essential role in B cell migration.
Expression has been reported in human blood, salivary gland, and various animal organs including lymphatic tissues, bone marrow, brain, liver, skin, spleen, stomach, and tonsil.
G-protein Coupled Receptors (GPCRs) share a structural motif of seven membrane-spanning helices and exist in active/inactive forms. GPCR activation and regulation are crucial for cellular signaling and pharmacological research.
Notably, GPCR-targeted drugs such as Zyprexa (Eli Lilly) and Claritin (Schering-Plough) demonstrate the therapeutic relevance of this receptor family.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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