Thermo Fisher Scientific CXCR5 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Target Information

CXCR5 (C-X-C Chemokine Receptor Type 5, CD185), also known as Burkitt lymphoma receptor 1 (BLR1), belongs to the CXC chemokine receptor family. It is a G protein-coupled seven-transmembrane receptor for chemokine BLC. CXCR5 is specifically expressed in Burkitt’s lymphoma and lymphatic tissues such as lymph node follicles and spleen, and plays an essential role in B cell migration.

CXCR5 expression has been observed in human blood and salivary gland, and in animal lymphatic organs including blood, bone marrow, brain, liver, lymph node, skin, spleen, stomach, and tonsil. ESTs have been isolated from human brain, germ cell, lung, lymph, and pancreas.

G-protein Coupled Receptors (GPCRs) form one of the largest families of signaling molecules, sharing a common structure of seven membrane-spanning helices. They exist in active and inactive forms, with ligand binding leading to signaling via G-proteins and downstream effectors. GPCR regulation plays a critical role in cellular physiology and pharmacological research, leading to the development of several GPCR-targeted drugs.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.