Thermo Fisher Scientific NAB2 Polyclonal Antibody
Thermo Fisher Scientific의 NAB2 Polyclonal Antibody는 인간 및 마우스 시료에 반응하며, 핵 내 NAB2 단백질 검출에 적합합니다. Western blot과 ELISA에 최적화된 항체로, 고순도 친화 크로마토그래피 정제 및 안정적 액상 형태로 제공됩니다.
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Thermo Fisher Scientific NAB2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–200 of human NAB2 (NP_005958.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.36 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914526 |
Product Specific Information
- Positive test controls: M21, Mouse lung, Mouse liver
- Localization: Nucleus
Immunogen sequence:
MHRAPSPTAE QPPGGGDSAR RTLQPRLKPS ARAMALPRTL GELQLYRVLQ RANLLSYYET FIQQGGDDVQ QLCEAGEEEF LEIMALVGMA TKPLHVRRLQ KALREWATNP GLFSQPVPAV PVSSIPLFKI SETAGTRKGS MSNGHGSPGE KAGSARSFSP KSPLELGEKL SPLPGGPGAG DPRIWPGRST PESDVGAGGE
Target Information
Transcriptional control is partly regulated by interactions between DNA-bound transcription factors, such as Egr-1/NGFI-A, and coregulatory proteins, such as NAB (NGFI-A-binding proteins). NAB1 and NAB2 are evolutionarily conserved corepressors of EGF-1/NGFI-A.
Both NAB1 and NAB2 contain:
- NAB conserved domain 1 (NCD1): Required for binding NGFI-A
- NCD2 domain: Responsible for repressor function
NAB2 is primarily localized in the nucleus and may play roles in downregulating NGFI-A activity and controlling cell division, differentiation, and apoptosis.
NAB2 has a predicted molecular mass of 56 kDa and localizes to chromosome 12q13.3–14.1, a region rearranged in several solid tumors, lipomas, and liposarcomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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