Thermo Fisher Scientific SRC2 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

PA1-846 detects glucocorticoid receptor interacting protein-1 (GRIP1) from hamster and human cells.
It has been successfully used in immunocytochemistry and immunofluorescence procedures.
Immunocytochemical staining of GRIP1 in CHO cells with PA1-846 results in cytoplasmic and nuclear staining.
This antibody has not been used successfully in Western blot procedures.

PA1-846 immunogen is a synthetic peptide corresponding to residues P(206) L P D S E E E G H D S(217) C of human GRIP1.
The PA1-846 immunizing peptide (Cat. # PEP-050) is available for use in neutralization and control experiments.

Target Information

SRC2 (steroid receptor coactivator 2), also known as nuclear receptor coactivator 2 (NCOA2) or TIF2, aids in the function of nuclear hormone receptors.
These receptors are conditional transcription factors that regulate cell growth, development, and homeostasis through gene expression control.
Members of the nuclear hormone receptor superfamily include steroid and class II nuclear receptors, each with N-terminal activation, DNA-binding, and C-terminal hormone-binding domains.
Upon hormone binding, the receptors undergo conformational changes, dissociate from inhibitory complexes, and bind DNA enhancer elements to modulate transcription.
Transcriptional coactivator proteins like SRC2 are required to mediate transcriptional activation after receptor binding.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.