Thermo Fisher Scientific DNA-PK Polyclonal Antibody
DNA 손상 반응 연구용 DNA-PKcs 폴리클로날 항체. Western blot, IHC, ICC, IP, ChIP 등 다양한 응용에 적합. Rabbit IgG 기반, Human DNA-PKcs fragment로 면역화. 연구용으로만 사용 가능.
- 판매단위
- pk
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Thermo Fisher Scientific DNA-PK Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
| Immunocytochemistry (ICC/IF) | 1:250 |
| Immunoprecipitation (IP) | Assay-dependent |
| ChIP assay (ChIP) | 2.5 µg/10^6 cells |
| Gel Shift (GS) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Hamster, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Human DNA-PKcs fragment |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | <0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2172840 |
Product Specific Information
Heat-mediated antigen retrieval using an antigen unmasking fluid is recommended, followed by a 2-hour incubation with the primary antibody.
Rabbit anti-DNA PKcs antibody recognizes the human DNA-dependent protein kinase catalytic subunit, also known as DNA-PKcs, DNPK1, or p460.
Target Information
DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. It is an atypical kinase closely related to PI3 kinases and can be inhibited by small molecules targeting PI3 kinases.
DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex required for the expression of most genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting pre-initiation complex formation.
Multiple transcript variants encoding different isoforms have been identified for DNA-PK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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