Thermo Fisher Scientific BRS3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:300–1:2,000

Immunohistochemistry (IHC)

• Tested Dilution: 1:300–1:2,000

Miscellaneous PubMed (Misc)

• Publications: 2 available (see references)

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
• The peptide is homologous in human and rat.
• Specificity: BRS3.

Target Information

BRS3 expression has been reported in lung (normal and cancer), nasal mucosa, placenta, and uterus. ESTs have been isolated from normal brain and kidney cancer libraries.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices and exist in both active and inactive forms.
An array of activating ligands participate in the conformation of GPCRs leading to signaling via G-proteins and downstream effectors. Ongoing studies have shown the vast series of reactions participating in the negative regulation of GPCRs. This “turn-off” activity has significant implications for cellular physiological action and continues to drive pharmacological research for new drug candidates.
Two major GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough), which dominate the mental health and allergy markets, respectively.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.