Thermo Fisher Scientific BRS3 Polyclonal Antibody
Thermo Fisher Scientific의 BRS3 Polyclonal Antibody는 Human, Mouse, Rat에 반응하며 Western blot 및 IHC에 적합합니다. Lyophilized 형태로 제공되며, 장기 보관 시 -20°C에서 안정적입니다. BRS3 특이 항체로 GPCR 관련 연구에 활용됩니다.
- 카탈로그번호
- OSB00040W-100UL
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:300–1:2,000
Immunohistochemistry (IHC)
- Tested Dilution: 1:300–1:2,000
Miscellaneous PubMed (Misc)
- Publications: 2 available (see references)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the internal region of mouse Bombesin Receptor 3 (BRS3) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
- The peptide is homologous in human and rat.
- Specificity: BRS3.
Target Information
BRS3 expression has been reported in lung (normal and cancer), nasal mucosa, placenta, and uterus. ESTs have been isolated from normal brain and kidney cancer libraries.
G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices and exist in both active and inactive forms.
An array of activating ligands participate in the conformation of GPCRs leading to signaling via G-proteins and downstream effectors. Ongoing studies have shown the vast series of reactions participating in the negative regulation of GPCRs. This “turn-off” activity has significant implications for cellular physiological action and continues to drive pharmacological research for new drug candidates.
Two major GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough), which dominate the mental health and allergy markets, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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