Thermo Fisher Scientific mature BDNF Polyclonal Antibody
Rabbit polyclonal antibody specific for mature BDNF. Validated for WB and IHC-P in human, mouse, and rat samples. Lyophilized format for stable long-term storage. Suitable for research on neuronal survival, differentiation, and synaptic regulation.
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- OSB00032W-100UL
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 | – |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:1,000 | – |
| Miscellaneous (PubMed) | – | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the internal region of human mature BDNF conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
- The peptide is homologous in rat and mouse.
- Specificity: mature BDNF.
Target Information
BDNF (Brain-Derived Neurotrophic Factor) is a neurotrophin family member synthesized as pre-proBDNF, cleaved to proBDNF, and further processed to the mature 14 kDa protein. Both proBDNF and mature BDNF are biologically active and secreted in synaptic vesicles.
BDNF is widely expressed in the central nervous system, promoting neuronal survival, differentiation, and synaptic regulation. It signals primarily through the TrkB receptor and also interacts with the p75-NTR receptor.
Reduced expression of BDNF has been observed in Alzheimer’s and Huntington’s disease, and it plays roles in stress response and mood regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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