Thermo Fisher Scientific BPI Polyclonal Antibody
Thermo Fisher Scientific의 BPI Polyclonal Antibody는 인간 BPI 단백질을 인식하는 토끼 유래 항체로, WB 및 IHC 분석에 적합합니다. 동결건조 형태로 제공되며 보존제가 포함되지 않습니다. 항균 단백질 연구 및 염증 반응 메커니즘 분석에 활용됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:100–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:100–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the N-terminal region of human CAP57 (BPI) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: BPI.
Target Information
The antimicrobial protein BPI is a 55 kDa protein found in the primary (azurophilic) granules of human neutrophils and also detected on the surface of neutrophils, small intestinal, and oral epithelial cells.
BPI binds with high affinity to the lipid A region of lipopolysaccharides (LPS) on gram-negative bacteria, leading to multiple anti-infective activities such as:
- Cytotoxicity via damage to bacterial membranes
- Neutralization of gram-negative bacterial LPS
- Opsonization to enhance phagocytosis
BPI may play a key role in LPS-triggered airway disease and inflammation processes.
A 21 kDa recombinant fragment, rBPI21, has shown protective effects against invasive pneumococcal disease.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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