Thermo Fisher Scientific IRF7 Polyclonal Antibody
IRF7 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등에 적합하며 인간, 마우스, 랫트 반응성을 보임. 항원 친화 크로마토그래피로 정제된 액상 형태로, 장기 보관 시 -20°C에서 안정적 유지.
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Thermo Fisher Scientific IRF7 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–1 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–5 µg/mL | 1 publication |
| Immunocytochemistry (ICC/IF) | 20 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide corresponding to 17 amino acids near the center of human IRF7 (amino acids 200–230). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2890457 |
Product Specific Information
Positive controls that may be used include:
- A549 Cell Lysate
- HeLa Cell Lysate
- HepG2 Cell Lysate
Target Information
Interferons (IFNs) are involved in numerous immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms.
During infection, host-virus interactions activate transcription factors such as IFN regulatory factor-3 (IRF3), which stimulate transcription of IFN-α/β genes.
IRF7 plays a role in transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes.
It is a key component in the innate immune pathway, interacting with Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM, functioning as an intermediate in TLR4 and TLR9 signaling.
There are at least four differentially spliced isoforms of IRF7, though their functions are not clearly established.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA5-114526_IRF7_Q92985-1_Rabbit.svg, PA5-114526_IRF7_Q92985-1_Rabbit_PDP.jpeg)
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