Thermo Fisher Scientific B7-H3 (CD276) Polyclonal Antibody
Thermo Fisher Scientific의 B7-H3 (CD276) Polyclonal Antibody는 인간, 마우스, 랫트에 반응하며 WB 및 IHC(P) 실험에 적합합니다. 항원 친화 크로마토그래피로 정제된 비결합 항체로, CD4+ 및 CD8+ T세포 활성 연구에 활용됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA5114525
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide corresponding to 19 amino acids near the carboxy terminus of CD276 (amino acids 484–534 of human CD276) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term storage, store at −20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2890419 |
Product Specific Information
Positive controls that may be used include:
- Human Spleen Tissue Lysate
- Mouse Spleen Tissue Lysate
Target Information
CD276 (B7-H3) is a member of the B7 family of co-stimulatory molecules. It is a type I transmembrane protein that:
- Induces proliferation of CD4+ and CD8+ T cells
- Enhances cytotoxic T cell generation
- Selectively stimulates interferon gamma production
Expression of CD276 can be induced on dendritic cells and monocytes by inflammatory cytokines and is widely expressed in peripheral tissues such as the heart, kidney, testis, and colon. In humans, CD276 exists as two isoforms resulting from gene duplication and differential splicing. It has therapeutic potential in regulating cell-mediated immune responses in cancer, particularly with anti-angiogenic therapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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