Thermo Fisher Scientific Phospho-RAD18 (Ser403) Polyclonal Antibody
RAD18 단백질의 Ser403 인산화 형태를 특이적으로 인식하는 폴리클로날 항체. Western blot 및 IHC(P) 검증 완료. 인간 및 생쥐 시료에 반응. PBS 기반 완충액에 50% 글리세롤 포함, -20°C 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RAD18 (Accession Q9NS91), corresponding to amino acid residues around phosphorylated Ser403. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816708 |
Product Specific Information
Antibody detects endogenous levels of RAD18 only when phosphorylated at Ser403.
Target Information
Human Rad18 (hRad18) is a homologue of the S. pombe Rad18. In yeast, Rad6 and Rad18 play crucial roles in post-replication repair, particularly in gap-filling of the daughter strand during replication of damaged DNA. The Rad6–Rad18 interaction is critical during lesion bypass, forming a tight complex through a conserved ring-finger motif. The Rad18–Rad6 complex binds damaged DNA sites via the single-stranded DNA binding property of Rad18, followed by degradation of stalled replication components through the ubiquitin-conjugating activity of Rad6.
Human RAD18 maps to chromosome 3p24–25, a region often deleted in lung, breast, ovary, and testis cancers. The human RAD18 gene encodes a protein of 495 amino acids with an approximate molecular weight of 56 kDa and is ubiquitously expressed across various human tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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