Thermo Fisher Scientific MDM4 Monoclonal Antibody (OTI2C1), TrueMAB
MDM4 단백질을 인식하는 Mouse IgG1 단일클론 항체. WB, IHC, ICC/IF 등 다양한 응용에 적합. 인간 시료 반응성, 동결건조 형태로 제공되며, 트레할로스 함유 PBS 버퍼에 저장. 연구용으로만 사용 가능.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific MDM4 Monoclonal Antibody (OTI2C1), TrueMAB
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2C1 |
| Immunogen | Full length human recombinant protein of human MDM4 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve an antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
MDM2 is a primary regulator of p53 protein stability. MDMX (also known as MDM4) inhibits MDM2-mediated degradation of p53 through distinct interactions. The MDMX gene is often amplified in malignant gliomas. ARF binds MDMX, sequestering it in the nucleolus and enhancing p53 transactivation. MDMX expression can counteract MDM2-induced p53 degradation while maintaining suppression of p53 activity. MDMX also binds and stabilizes p73, increasing its half-life.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.