Thermo Fisher Scientific Kindlin 3 Polyclonal Antibody
Kindlin 3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간, 마우스, 랫트 반응성. Western blot에 적합하며 항원 친화 크로마토그래피로 정제됨. 액상 형태로 1 mg/mL 농도, 냉장 또는 냉동 보관 가능.
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Thermo Fisher Scientific Kindlin 3 Polyclonal Antibody
Applications
- Western Blot (WB): Tested dilution 1–2 µg/mL
- Suggested positive control: Rat spleen tissue lysate
- Compatible blocking peptide: PEP-0718
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 19 amino acid peptide near the carboxy terminus of human KINDLIN3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Refrigerate at 2–8°C for up to 3 months; for long-term storage, store at −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154448 |
Target Information
The KINDLIN family consists of three focal adhesion proteins that localize to integrin adhesion sites. These proteins contain a centrally located FERM domain interrupted by a pleckstrin homology (PH) domain.
KINDLIN1 and KINDLIN2 are widely expressed and play essential roles in integrin-mediated adhesion and spreading, whereas KINDLIN3 is restricted to hematopoietic cells, particularly megakaryocytes and platelets.
Misregulation of KINDLIN expression has been associated with various cancers. Studies suggest KINDLIN3 is critical for platelet integrin activation and outside-in signaling, making it a potential therapeutic target for modulating integrin activation in platelets and leukocytes.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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