Thermo Fisher Scientific GNA11 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: HeLa, mouse kidney, rat brain
• Predicted reactivity: Mouse (99%), Rat (98%), Xenopus laevis (97%), Dog (99%), Pig (97%), Chicken (100%), Rhesus Monkey (100%), Bovine (98%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Heterotrimeric guanine nucleotide-binding proteins (G proteins) consist of α, β, and γ subunits and mediate the effects of hormones, neurotransmitters, chemokines, and sensory stimuli. Over 20 known Gα subunits have been classified into four families—Gα(s), Gα(i/o), Gα(q), and Gα(12)—based on structural and functional similarities. Phosphorylation of Tyr356 of Gα(q)/Gα(11) is essential for activation of the G protein, since phenylalanine substitution for Tyr356 changes the interaction of Gα with receptors and abolishes ligand-induced IP3 formation.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 없음)