Thermo Fisher Scientific Cytokeratin 14 (KRT14) (Squamous Cell Marker) Monoclonal Antibody (KRT14/4129)
인체 KRT14 단백질을 표적으로 하는 단클론 항체로, 상피세포 및 편평세포암 마커 연구에 적합. IHC 및 Peptide Array에 사용 가능하며, 단백질 A/G로 정제된 액상 형태. 연구용으로만 사용.
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Thermo Fisher Scientific Cytokeratin 14 (KRT14) (Squamous Cell Marker) Monoclonal Antibody (KRT14/4129)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2c, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | KRT14/4129 |
| Immunogen | Recombinant fragment (around aa351–472) of human KRT14 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cytokeratins (CK) are intermediate filaments of epithelial cells, found in both keratinizing tissue (e.g., skin) and non-keratinizing cells (e.g., mesothelial cells). At least 20 different CKs can be identified. Most members of the CK family fall into two classes:
- Type I (acidic polypeptides)
- Type II (basic polypeptides)
Keratin 14, belonging to the type I subfamily, forms complexes with keratin 5 and helps distinguish stratified epithelial cells from simple epithelial cells. It is useful for identifying squamous cell carcinomas and is considered a prognostic marker in breast carcinomas. At least one member of each family (acidic and basic) is expressed in all epithelial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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