Thermo Fisher Scientific MLH1 Monoclonal Antibody (UMAB191), UltraMAB
MLH1 단백질을 인식하는 mouse IgG1 단일클론 항체로, Western blot, IHC, ICC/IF에 사용 가능. 인간 MLH1(aa 299-527) 재조합 단백질로 면역화. 고순도 친화 크로마토그래피 정제, 동결건조 형태로 제공. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunocytochemistry (ICC/IF) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | UMAB191 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 299–527 of human MLH1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
MLH1 is a DNA mismatch repair protein essential for maintaining genetic integrity. Defects in mismatch repair pathways can lead to microsatellite instability (MSI), which is associated with carcinogenesis. Mutations in mismatch repair genes such as MLH1 are linked to hereditary nonpolyposis colon cancer (HNPCC). MSH2 participates in the initial recognition of mismatched nucleotides, followed by MLH1-PMSH heterodimer formation to facilitate repair.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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