Thermo Fisher Scientific MET Monoclonal Antibody (UMAB190), UltraMAB

Applications

Western Blot (WB)

• Assay-dependent

Immunohistochemistry (Paraffin) (IHC (P))

• Dilution: 1:150

Immunocytochemistry (ICC/IF)

• Dilution: 1:150

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

MET (cMET) is a receptor-like tyrosine kinase implicated in various human malignancies. Upon ligand activation, MET interacts with PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3, triggering signaling cascades such as RAS-ERK, PI3K-AKT, and PLCγ-PKC.
It plays critical roles in embryonic development (gastrulation, muscle and neuron development, angiogenesis, kidney formation) and adult processes (wound healing, organ regeneration, tissue remodeling).
MET dysregulation is associated with cancers including gastric, renal, and breast, making it a key target for cancer research and diagnostics.

For Research Use Only. Not for use in diagnostic procedures or resale without express authorization.