Thermo Fisher Scientific CD19 Monoclonal Antibody (771404)
Rat CD19 단백질을 인식하는 Mouse IgG2b 단클론 항체로, Western blot 및 IHC(F) 실험에 적합합니다. CHO 유래 재조합 단백질을 면역원으로 제작되었으며, 단백질 A/G로 정제된 동결건조 형태입니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | 8–25 µg/mL | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 771404 |
| Immunogen | CHO-derived recombinant rat CD19 (Met1–Gly287) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2576241 |
Product Specific Information
Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.
Target Information
CD19 is a member of the immunoglobulin superfamily and contains two Ig-like domains. It is expressed on 100% of peripheral B cells, as defined by expression of kappa or lambda light chains. CD19 is also found on certain myeloid leukemia cells, particularly of monocytic lineage. It is the earliest and broadest B cell–restricted antigen and serves as a key regulator of normal and malignant B cell proliferation.
CD19 functions as a signal-amplifying coreceptor for the B cell receptor (BCR), lowering the threshold for antigen receptor–dependent stimulation. It can also signal independently of BCR co-ligation and acts as a central regulatory component for multiple signaling pathways. Mutations in the CD19 gene can cause hypogammaglobulinemia, while overexpression leads to B cell hyperactivity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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