Thermo Fisher Scientific FZD7 Monoclonal Antibody (151143)
FZD7 단일클론 항체로 인간 및 마우스 시료에 반응하며 ICC/IF, Flow Cytometry에 적합. 단백질 A/G로 정제된 무보존제 동결건조 형태. Wnt 신호 관련 FZD7 수용체 연구용으로 사용.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 8–25 µg/mL
Flow Cytometry (Flow)
- Tested Dilution: 2.5 µg per million cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 151143 |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse Frizzled-7 (Gln33–Leu185) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2610095 |
Product Specific Information
- In direct ELISAs, no cross-reactivity with recombinant mouse Frizzled-1, -3, -4, or -8 is observed.
- Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Members of the frizzled gene family encode 7-transmembrane domain proteins that act as receptors for Wnt signaling proteins.
The FZD7 protein includes:
- N-terminal signal sequence
- 10 cysteine residues typical of the cysteine-rich extracellular domain of Frizzled family members
- 7 transmembrane domains
- Intracellular C-terminal tail with PDZ domain-binding motif
FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signaling in poorly differentiated human esophageal carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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