Thermo Fisher Scientific PMP70 Polyclonal Antibody
Rabbit polyclonal antibody against PMP70 for detection in WB, IHC, ICC/IF, Flow, and IP. Recognizes human, mouse, and rat PMP70. Validated in multiple publications. Supplied as liquid, 1 mg/mL, antigen affinity purified, stored at -20°C.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500 | View 12 publications |
| Immunohistochemistry (IHC) | - | View 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1–10 µg/mL | View 11 publications |
| Flow Cytometry (Flow) | 0.5 µg/test | View 2 publications |
| Immunoprecipitation (IP) | - | View 1 publication |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Hamster, Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic Peptide: C N(644) Y E F K K I T E D T V E F G S(659) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
| RRID | AB_2219912 |
Product Specific Information
PA1-650 detects peroxisomal membrane protein 70 (PMP70) from mouse tissues.
It has been successfully used in Western blot, flow cytometry, and immunofluorescence procedures.
By Western blot, this antibody detects an ~70 kDa protein representing PMP70 from peroxisome-enriched fractions from L cells.
The immunizing peptide corresponds to amino acid residues 644–659 from rat PMP70.
This sequence is completely conserved in mouse PMP70 and differs from human PMP70 by a single amino acid substitution.
PA1-650 immunizing peptide (Cat. # PEP-038) is available for use in neutralization and control experiments.
Target Information
Peroxisomes are single-membrane organelles involved in various biochemical pathways and present in most eukaryotic cells.
They participate in the modification of toxins such as phenols, alcohols, and aldehydes, and in long-chain fatty acid metabolism via beta-oxidation.
Loss of peroxisomal function can result in diseases such as Zellweger syndrome, hyperpipecolic acidemia, neonatal adrenoleukodystrophy, and infantile Refsum disease.
Peroxisomal membrane protein 70 (PMP70) is an abundant, integral membrane protein of the peroxisome.
It is induced by treatment with hypolipidemic agents, which also stimulate peroxisome proliferation and beta-oxidation enzyme activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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