Thermo Fisher Scientific PMP70 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

PA1-650 detects peroxisomal membrane protein 70 (PMP70) from mouse tissues.
It has been successfully used in Western blot, flow cytometry, and immunofluorescence procedures.
By Western blot, this antibody detects an ~70 kDa protein representing PMP70 from peroxisome-enriched fractions from L cells.

The immunizing peptide corresponds to amino acid residues 644–659 from rat PMP70.
This sequence is completely conserved in mouse PMP70 and differs from human PMP70 by a single amino acid substitution.
PA1-650 immunizing peptide (Cat. # PEP-038) is available for use in neutralization and control experiments.

Target Information

Peroxisomes are single-membrane organelles involved in various biochemical pathways and present in most eukaryotic cells.
They participate in the modification of toxins such as phenols, alcohols, and aldehydes, and in long-chain fatty acid metabolism via beta-oxidation.
Loss of peroxisomal function can result in diseases such as Zellweger syndrome, hyperpipecolic acidemia, neonatal adrenoleukodystrophy, and infantile Refsum disease.

Peroxisomal membrane protein 70 (PMP70) is an abundant, integral membrane protein of the peroxisome.
It is induced by treatment with hypolipidemic agents, which also stimulate peroxisome proliferation and beta-oxidation enzyme activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.