Thermo Fisher Scientific ASAH1 Polyclonal Antibody
ASAH1 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간 및 다양한 종에서 반응합니다. Western blot과 IHC(Paraffin) 실험에 적합하며, 고순도 친화 크로마토그래피로 정제된 액상 형태입니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
- Publications: [References not provided]
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- Publications: [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ASAH1 (Accession Q13510), corresponding to amino acid residues L12–W62 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2815619 |
Product Specific Information
Antibody detects endogenous levels of total ASAH1.
Target Information
ASAH1 encodes a member of the acid ceramidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. The processing of this preproprotein generates alpha and beta subunits that heterodimerize to form the mature lysosomal enzyme, which catalyzes the degradation of ceramide into sphingosine and free fatty acid.
This enzyme is overexpressed in multiple human cancers and may play a role in cancer progression. Mutations in this gene have been linked to the lysosomal storage disorder Farber lipogranulomatosis and the neuromuscular disorder spinal muscular atrophy with progressive myoclonic epilepsy.
Related pathways include Innate Immune System and Sphingolipid metabolism.
Diseases associated with ASAH1 include Farber Lipogranulomatosis and Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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