Thermo Fisher Scientific Progesterone Receptor Monoclonal Antibody (R.380.2)
Rabbit monoclonal antibody (clone R.380.2) specific for human progesterone receptor. Validated for WB, IHC (Paraffin), and ICC/IF applications. High specificity, unconjugated form, suitable for reproductive and nuclear receptor studies.
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- MA514841
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | R.380.2 |
| Immunogen | Synthetic peptide corresponding to residues surrounding Tyr541 of human progesterone receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 40 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10977519 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with other PR family members.
Target Information
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. It mediates the physiological effects of progesterone, which plays a central role in reproductive events such as the establishment and maintenance of pregnancy.
PR exists as two forms:
- PR-A (94 kDa): Contains a 165 amino acid deletion at the N-terminus, exposing a 140 amino acid inhibitory domain that represses transcriptional activity.
- PR-B (120 kDa): Transcriptionally active form responsible for gene activation related to endometrial maintenance, pregnancy, and ovulation inhibition.
In its inactive state, PgR forms a multiprotein complex with heat shock proteins and immunophilins. Binding of progesterone induces a conformational change, enabling receptor dimerization and binding to progesterone response elements (PRE), leading to activated transcription.
A null mutation in the PGR gene results in pleiotropic reproductive abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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