Thermo Fisher Scientific Progesterone Receptor Monoclonal Antibody (R.809.9)
Thermo Fisher의 R.809.9 클론 프로게스테론 수용체 단일클론 항체는 인간 시료에 반응하며, WB, IHC, ICC/IF, Flow Cytometry 등에 적합합니다. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공되며, -20°C 보관이 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:800 | 1 publication |
| Immunocytochemistry (ICC/IF) | 1:200–1:800 | 1 publication |
| Flow Cytometry (Flow) | 1:200 | 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | R.809.9 |
| Immunogen | Synthetic peptide corresponding to residues surrounding Ser115 of human progesterone receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 243 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10984856 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with other PR family members.
Target Information
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy.
PR exists as two forms: a 94 kDa protein (Form A) and a 120 kDa protein (Form B), due to alternative translation initiation sites. PR-B is transcriptionally active, responsible for activating genes involved in endometrial maintenance, pregnancy, and inhibition of ovulation.
PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus, exposing a 140 amino acid inhibitory domain that represses steroid hormone transcriptional activity.
In its inactive state, PgR forms a multiprotein complex with heat shock proteins and immunophilins. Upon progesterone binding, conformational changes lead to receptor dimerization and binding to progesterone response elements (PRE), activating transcription.
A null mutation in the PGR gene leads to reproductive abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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