
Thermo Fisher Scientific USP7 Monoclonal Antibody (OTI3D5), TrueMAB
USP7 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot 및 IHC에 적합. 인간 시료 반응성. 동결건조 형태로 제공되며 PBS 기반 버퍼 포함. 연구용으로 p53 안정화 관련 단백질 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3D5 |
| Immunogen | Full length human recombinant protein of human USP7 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
USP7 (also known as HAUSP) is a ubiquitin-specific protease that removes ubiquitin from substrate proteins.
It plays a crucial role in stabilizing proteins such as p53 by antagonizing Mdm2-mediated degradation.
HAUSP may function as a tumor suppressor by protecting p53 under stress conditions.
Additionally, HAUSP is implicated in oncogenic pathways involving Myc and E1A, potentially providing an alternative mechanism for cellular protection against oncogenic insults.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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