Thermo Fisher Scientific SERPINB6 Monoclonal Antibody (OTI2F8), TrueMAB
SERPINB6 단백질을 인식하는 마우스 모노클로날 항체로 Western blot 및 IHC(파라핀) 적용 가능. HEK293T 세포에서 발현된 full-length 인간 SERPINB6 항원을 사용해 제작. PBS buffer에 동결건조 형태로 제공되며, 연구용으로 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2F8 |
| Immunogen | Full length human recombinant protein of human SERPINB6 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The SERPINB6 gene encodes a member of the serpin superfamily, specifically the ovalbumin-serpin subfamily. Initially identified as a placental thrombin inhibitor, the mouse homolog is expressed in inner ear hair cells.
Mutations in this gene are linked to nonsyndromic progressive hearing loss, indicating its role in protecting inner ear cells from lysosomal leakage during stress. Loss of this protection can lead to cell death and sensorineural hearing loss.
Alternatively spliced transcript variants have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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