Thermo Fisher Scientific Parvalbumin Monoclonal Antibody (C12), FITC
Parvalbumin 단백질을 검출하기 위한 FITC 결합 단클론 항체. Western blot, IHC, ICC/IF, ELISA에 사용 가능. 사람, 생쥐, 랫트 반응성. 단백질 A 정제, 보존제 없음. 4°C 암소 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (IHC) | 1:100 |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | C12 |
| Immunogen | Synthetic peptide from the full length Rat Parvalbumin protein |
| Conjugate | FITC |
| Excitation/Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 9.09 mM sodium bicarbonate/PBS, pH 7.4, with 640.91 mM DMSO, 136.36 mM ethanolamine |
| Contains | No preservative |
| Storage Conditions | 4°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2932382 |
Additional Conjugate Formats
- APC (Cat. MA5-45927)
- PerCP (Cat. MA5-45929)
- Custom conjugation available upon request
Product Specific Information
A 1:500 dilution of MA5-45928 was sufficient for detection of Parvalbumin in 15 µg of Rat Brain by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Detects a 12 kDa protein.
Target Information
Parvalbumin (PV) is a calcium-binding protein expressed in specific muscle fibers and fast-firing neurons. It belongs to the EF-hand protein family and plays a key role in calcium decay during muscle contraction and relaxation cycles.
Parvalbumin expression correlates with muscle relaxation rate and is also found in GABAergic interneurons that help maintain excitation-inhibition balance in the cortex and hippocampus.
In amyotrophic lateral sclerosis (ALS), parvalbumin immunoreactivity is absent from neuron populations lost early in disease progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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