Thermo Fisher Scientific CHMP3 Polyclonal Antibody
CHMP3 단백질을 인식하는 양(IgG) 폴리클로날 항체로, 인간·생쥐·랫트 반응성. WB 및 IHC에 사용 가능하며, 합성 펩타이드 항원 기반. 동결건조 형태로 제공되며 PBS 버퍼에 보존. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the N-terminal of human CHMP3 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
- The antigen is homologous in rat and mouse.
- Specificity: CHMP3.
Target Information
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III), which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs.
MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are mostly delivered to lysosomes for degradation of membrane proteins, lysosomal enzymes, and lipids.
The MVB pathway requires sequential function of ESCRT-O, -I, -II, and -III complexes. ESCRT-III proteins dissociate before ILV release and are involved in membrane fission events such as cytokinesis and viral budding (HIV-1 and other lentiviruses).
ESCRT-III proteins mediate vesicle extrusion and membrane fission activities, possibly with AAA ATPase VPS4.
Selectively binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) and PtdIns(3,4)P2.
Involved in late stages of cytokinesis and endosomal sorting/trafficking of EGF receptor.
Isoform 2 prevents stress-mediated cell death and accumulation of reactive oxygen species in yeast cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: OSC00128G-500UG_CHMP3_Q9Y3E7-1_Sheep.svg, OSC00128G-500UG_CHMP3_Q9Y3E7-1_Sheep_PDP.jpeg)
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