Thermo Fisher Scientific CAP-18 Polyclonal Antibody
Thermo Fisher Scientific의 CAP-18 Polyclonal Antibody는 인간 Cathelicidin 단백질을 인식하는 Sheep 유래 항체입니다. Western blot과 IHC에 적합하며, 동결건조 형태로 제공됩니다. 감염 방어 및 면역 반응 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Sheep / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from amino acid region 70–110 of human CAP-18 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: Cathelicidin antimicrobial peptide.
Target Information
Cathelicidin is an epithelial-derived antimicrobial protein found in specific granules of polymorphonuclear leukocytes of bone marrow, testis, and neutrophils. Cathelicidins are a family of antimicrobial peptides characterized by conserved pro-peptide sequences identified in epithelial tissues and some myeloid cells of humans and animals.
LL-37/hCAP-18 is the only Cathelicidin found in humans and is expressed in inflammatory and epithelial cells. These molecules are essential for defense against invasive bacterial infection in the skin.
Beyond their direct antimicrobial function, Cathelicidins play multiple roles in innate and adaptive immunity, including:
- Endotoxin neutralization
- Angiogenesis
- Wound healing
- Promotion of neutrophil chemotaxis and mast cell recruitment
Cathelicidin antimicrobial peptides are prototypes of innovative drugs that may be used to treat infection and/or modulate immune responses.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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